Researchers have successfully reported a case where a 68-year old diabetic patient was successfully treated with a personalized bacteriophage-based treatment. The patient suffered from necrotizing pancreatitis that had previously been unresponsive to routine antibiotic treatment.
A new mathematical modelling study has estimated the mortality rates of TB in the pediatric population, producing the first ever estimate for infants under 5 years of age.
Novel research suggests that type III interferon-mediated signalling could play a major role in controlling live-attenuated yellow fever virus infection in mice.
Resistance to Naphthoquine has been found in mouse models and might emerge in future as widely used. In this article, the in vivo antimalarial activity of novel naphthoquine derivatives is assessed revealing promising antimalarial candidates for further research.
Inappropriate use and overuse of antibiotics are among the most important factors in resistance development, and effective antibiotic stewardship measures are needed to optimize outcomes.
The pathogenicity of T. marneffei depends on the ability of the fungus to survive the killing process and replicate inside the host macrophage cells. This paper summarizes factors relating to the stress responses that contribute to the intracellular survival of T. marneffei