TB or not TB? Improving the understanding and diagnosis of tuberculosis through metabolomics

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Despite the major discovery in 1882 by Robert Koch that the causative agent for tuberculosis (TB) is the infectious bacteria Mycobacterium tuberculosis, and all the genomics, transcriptomics and proteomics data collected on this organism, and the subsequent vaccination, diagnostic and treatment approaches developed since then, TB is still a major global health problem. TB reportedly occurs in approximately a third (1.9 billion) of the world’s population either in its active (symptomatic) or latent (asymptomatic) form, which subsequently results in the death of 1.5 million individuals per annum, ranking it the world’s foremost cause of death from a single infectious bacterial agent [1].

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