Original Publication Date: 12 June, 2017
Publication / Source: Future Microbiology
Authors: Thaiss CA, Shapiro H& Elinav E
The prevalence of obesity is globally increasing and is associated with a reduction in life expectancy and quality of life worldwide . Obesity confers a major risk factor for the development of metabolic syndrome, consisting of co-occurring pathologies such as Type 2 diabetes, cardiovascular diseases and nonalcoholic fatty liver. Dieting is one of the major approaches to target obesity. Even a modest reduction in weight can ameliorate Type 2 diabetes, hypertension and the risk for development of cardiovascular diseases . Nonetheless, many dietary approaches fail due to difficulties in long-term post-dieting weight maintenance, caused by rapid weight regain that initiates repeated cycles of weight loss and regain (typically referred to as ‘yo-yo’ dieting).