Biocompatible nickel-prussian [email protected] nanocomposites show potent antibacterial activities

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Aim: Silver nanoparticles have long been used as potent antibacterial agents. However, toxicity concerns of silver nanoparticles have limited their successful clinical applications. Hence, development of silver-based novel biocompatible nanomaterials for antibacterial applications is a challenging task. Materials & methods: Accordingly, in this work, we synthesized a biocompatible silver-based nanocomposite for antibacterial applications. The nanocompostie was characterized by several analytical techniques. The nanocomposite was further tested for its cytotoxicity in cells, chicken embryo and bacteria. Results & Conclusion: Herein, we report a simple and cost-effective method for the synthesis of nickel-prussian [email protected] nanocomposites. The nanocomposite is highly stable and shows biocompatibility observed by in vitro assay and by ex vivo chicken embryonic angiogenesis assay. The nanocomposite exhibits profound antibacterial activity toward Gram-negative (Escherichia coli) and Gram-positive (Bacillus subtillus) bacteria. The results altogether suggest the future potential applications of nickel-prussian [email protected] nanocomposite as an antibacterial agent.

Prussian blue nanoparticles (PBNPs) and their analogs have been used for various biomedical applications including drug delivery [1–3], imaging [4], MRI contrast agent [5], biosensors [6], photoacoustic imaging contrast agents [7] and photothermal ablation agents [8] due to their high biocompatibility, low production cost, ease of surface modification and high drug loading.

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