Original Publication Date: 6 September, 2017
Publication / Source: Future Science OA
Authors: Mukherjee S, Das S , Nuthi S & Patra CR
Aim: Silver nanoparticles have long been used as potent antibacterial agents. However, toxicity concerns of silver nanoparticles have limited their successful clinical applications. Hence, development of silver-based novel biocompatible nanomaterials for antibacterial applications is a challenging task. Materials & methods: Accordingly, in this work, we synthesized a biocompatible silver-based nanocomposite for antibacterial applications. The nanocompostie was characterized by several analytical techniques. The nanocomposite was further tested for its cytotoxicity in cells, chicken embryo and bacteria. Results & Conclusion: Herein, we report a simple and cost-effective method for the synthesis of nickel-prussian blue@silver nanocomposites. The nanocomposite is highly stable and shows biocompatibility observed by in vitro assay and by ex vivo chicken embryonic angiogenesis assay. The nanocomposite exhibits profound antibacterial activity toward Gram-negative (Escherichia coli) and Gram-positive (Bacillus subtillus) bacteria. The results altogether suggest the future potential applications of nickel-prussian blue@silver nanocomposite as an antibacterial agent.
Prussian blue nanoparticles (PBNPs) and their analogs have been used for various biomedical applications including drug delivery [1–3], imaging , MRI contrast agent , biosensors , photoacoustic imaging contrast agents  and photothermal ablation agents  due to their high biocompatibility, low production cost, ease of surface modification and high drug loading.
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