Searching for a HIV vaccine – the closest candidates

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Ever since the identification of the HIV virus in 1984, the search for a vaccine has been of high priority. However, there has been no end of challenges encountered, primarily owing to the nature of the HIV virus and its lifecycle, and in many cases these challenges still need to be overcome [1].

So where are we on the path to a vaccine? To date there have only been a handful of Phase III efficacy trials for HIV vaccine candidates, which have had varied, and in some cases controversial, results. Here we review the history of HIV vaccine efficacy studies and look into the vaccine candidates closest to front-line use.

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