Ebola: newly identified host factor could be a target for intervention

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Researchers at the University of Copenhagen (Denmark) and Phillips Universität Marburg (Germany) have manipulated a host enzyme recruited by the Ebola virus, demonstrating that inhibition of this pathway can prevent replication and infection, and presenting a potential target for therapeutic intervention.

It was previously understood that the transcription of Ebola virus’ genome relied on the viral transcription factor VP30, however, the underlying molecular mechanism remained unknown. This study, published recently in Molecular Cell, discovered a new host factor for the Ebola virus, which the pathogen utilizes to replicate.

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