Can previous influenza virus exposure enhance susceptibility to subsequent infection?

Scientists from McMaster University (Ontario, Canada) and the Université de Montréal (Montreal, Canada) were part of a research collaboration to better understand influenza circulation trends in order to deploy appropriate vaccination programs.

Every winter, influenza A virus resurfaces, causing a major threat to global public health due to its ability to mutate rapidly and circumvent the present day vaccine and potentially cause a pandemic. For example, one of the strains circulating this year, H3N2 or ‘aussie flu’, has made its way across the waters and is currently causing a steep rise in influenza cases across the UK.

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    • Hi Wouterhavinga,

      Thanks for your comment, in this study the authors don’t comment on ADE, however, as you point out ADE has been implicated in influenza. For example, it is thought to be one of the obstacles facing the development of a universal flu vaccine. However, the literature on ADE in influenza seems limited, compared to dengue, so perhaps this is an area requiring more research?

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