Investigating heat-shock gene htpG and the production of virulence factors in Pseudomonas aeruginosa

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Pseudomonas aeruginosa is one of the most clinically important opportunistic pathogen in humans and is the primary cause of mortality in patients suffering cystic fibrosis. The pathogenesis of these bacteria is dependent on biofilm formation and the production of multiple virulence factors.

This study, recently published in Future Microbiology, aimed to study the effects of encoded heat-shock protein 90 homolog (htpG) on the selected virulence factors responsible for pathogenesis and biofilm formation of P. aeruginosa. The researchers characterized a mutant of P. aeruginosa, without htpG in order to identify its role; with the hope their findings might indicate new cellular targets for antibacterial therapies.

“The heat-shock response is one of the best described cellular adaptations to stress conditions. Exposure of cells to high temperature and other environmental stresses induces the synthesis of a group of proteins named HSPs. HSPs can bind other proteins and influence their folding, oligomeric assembly, stabilization, transport across membranes and degradation.”

Read the full article in Future Microbiology

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