About AMR: Leveraging host signaling pathways to control TB infections

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In a recent study published in Nature Communications, researchers validated a novel screening approach to identify host-directed compounds that reduce the replication of intracellular pathogens.

By coupling an intracellular survival assay with a data-driven in silico predictive model, the researchers identified receptor tyrosine kinase (RTK) signaling as an important host pathway that controls intracellular bacterial survival, and validated new drug candidates that target RTK signaling and therefore could be used to treat multidrug-resistant infections.

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