Could serum IgA responses from gut microbes protect against sepsis?

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In a recently published study, researchers identified that exposing mice to particular microbes increased their blood levels of IgA antibodies, which protected them against polymicrobial sepsis.

The link between IgA responses to gut microbes and IgA-specific components of intestinal bacteria in mice serum has been demonstrated in previous work. It was also reported that individuals with IgA deficiencies were more likely to develop sepsis; however, whether these two observations are associated with each other remained uncertain.

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