ASM Microbe: How do bacteria ‘eat’ bone to sustain invasive infection?

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Research fronted by scientists from the Vanderbilt University Medical Center (TN, USA) has revealed the metabolic pathway that Staphylococcus aureus use to survive in bones. These findings were presented at ASM Microbe (7–11 June) in Atlanta (GA, USA).

Bone is one of the most frequently affected sites of infection for invasive S. aureus, which is paradoxical when considering the tissue properties of the skeleton. In particular, bone has low oxygen concentrations and is constantly being destroyed and reformed by osteoblasts and osteoclasts.

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