Could bacterial immunotherapy replace antibiotics against Gram-negative bacteria?

Immunotherapy has demonstrated the ability to destroy cancer cells, so why not use the immune system to fight bacteria? The human immune system’s ability of preventing entry and colonization of pathogens could be employed to defeat antibiotic-resistant bacteria – this is the philosophy behind bacterial immunotherapy.

Researchers from Lehigh University (PA, USA), led by Marcos Pires, have found promise in small-molecule compounds designed to tag the cell surface of Gram-negative bacteria. Specifically, the team observed a significant decrease in the number of live bacteria when using the small-molecule compound in experiments on E. coli in human serum.

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