CRISPR–Cas9 gene drive used to collapse malaria-carrying mosquito populations

Scientists at Imperial College London (UK) have recently reported a first-time success in effectively blocking female mosquito reproduction, eliminating a caged population of Anopheles gambiae in only 7–11 successive generations.

The team utilized gene drive technology to design a CRISPR–Cas9 construct to selectively disrupt a female-specific transcript of doublesex (dsx) gene, a sex-determining gene. This research designing a gene drive with the ability to diminish malaria vector populations is an area with huge potential to abate malaria transmission.

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