Allison J. Lopatkin, PhD, works as a Postdoctoral Fellow in the Institute for Medical Engineering and Sciences at the Massachusetts Institute of Technology and the Infectious Disease and Microbiome group at the Broad Institute of MIT and Harvard (both MA, USA), as a member of the Collins Lab. She completed her PhD training in Biomedical Engineering at Duke University (NC, USA), and her BS training in Applied Mathematics at the University of Rochester (NY, USA). Allison’s work uses quantitative methods to study the spread of antibiotic resistance within bacterial populations, including synthetic biology approaches and mathematical modeling. Her current research interests include evolutionary dynamics of bacterial communities, leveraging horizontal gene transfer to target pathogens, and adjuvant discovery to extend the efficacy of existing antibiotics.
See more from Allison:
Antibiotic tolerance significantly reduces antibiotic efficacy and contributes to treatment failure; targeting both antibiotic tolerance and antibiotic resistance is critical to develop new antimicrobial strategies that will successfully eradicate hard-to-treat infections.
More focus should be put on determining if pathogens are resistant or resilient to antibiotics, according to a new study. This distinction could allow for improved, personalized treatment and help to preserve current antibiotics.
Researchers have demonstrated that antibiotic-resistance plasmids persist in the absence of antibiotics, provided that the efficiency of plasmid transfer exceeds a critical threshold, highlighting the limitations of ‘resistance-reversal’ strategies.