Do basophils hold a key role in fighting bacterial infection?

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Scientists from Seattle Children’s Research Institute (WA, USA) have revealed that basophils play an important role in the immune response to bacterial infections, preventing the development of sepsis.

The study, published recently in Nature Immunology, looks into the aberrant immune response that occurs in sepsis, as principal investigator Adrian Piliponsky (Seattle Children’s) explained: “Sepsis is the number one killer of children globally, yet little is known about what goes wrong in an individual’s immune system to cause sepsis as it fights off an infection. Without this information, it’s hard to predict who will develop sepsis or explain why sepsis causes a range of immune responses in different individuals.”

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