Slow-release delivery strategies provide better immunity for HIV vaccine

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Delivering HIV vaccines via slow-release methods has enhanced the protective immune response in preclinical models, according to new research from the La Jolla Institute for Immunology (CA, USA).

The researchers have discovered that delivering a HIV vaccine in small doses over a period of days leads to a stronger immune response compared with administering the vaccine in a single dose. The team suggest that this escalating dose delivery method could be carried forwards into future clinical trials for testing.

The study, published recently in Cell, compared three vaccine dosage strategies in rhesus monkeys to understand the impact they might have on neutralizing antibody production. The strategies were: a traditional single administration, an ‘osmotic pump’ strategy, where an implant released the vaccine slowly, and an escalating dose strategy, where animals were given partial doses of the vaccine every other day for 12 days.

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