Coagulation factors show activity against drug-resistant Gram-negative bacteria

Coagulation factors, which are involved in blood clotting, could have antibacterial activity against drug-resistant Gram-negative bacteria, according to a study from Cell Research.

Previously, a deficiency in blood clotting factors as seen in patients with haemophilia has been associated with increased likelihood of bacterial infections, including pneumonia and sepsis, suggesting these factors might have antibacterial properties.

In this study a team from Sichuan University (China) investigated factors VII, IX and X against Gram-negative pathogens including Pseudomonas aeruginosa and Acetinobacter baumannii.

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