Losing control of HIV: KLF2 could trigger impaired T-cell function

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‘Controller’ patients naturally suppress HIV infection, but in some patients increased KLF2 expression and impaired T-cell function triggers T cells to abort natural HIV control.

A research group from the Ragon Institute of Massachusetts General Hospital (MA, USA) has uncovered new stages preceding the loss of natural HIV control in a small group of ‘controller’ patients. The study, led by first author David Collins, investigated how some controller patients who naturally suppress HIV infection later lose this ability, identifying elevated KLF2 expression and subsequent T-cell impairment as preceding causes. These findings provide insight into the immune interaction with HIV and may help develop new HIV treatments and vaccines.

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