Hold the antibiotics: next-generation hydrogels have arrived

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Scientists in Sweden have created a new class of non-antibiotic hydrogel capable of fighting multidrug-resistant (MDR) bacterial infections by enhancing the skin’s natural immune defense.

A recent study led by co-first authors Yamiao Fan, from the KTH Royal Institute of Technology (KTH RIT; Stockholm, Sweden), and Soumitra Mohanty (Karolinska Institutet and Karolinska University Hospital both Stockholm, Sweden), reveals a new treatment in the fight against antibiotic resistance. The team developed a dendritic macromolecule-based polymer hydrogel and evaluated the material for cytotoxicity and antibacterial capabilities. The study demonstrates a new class of cationic dendritic hydrogels capable of eliminating bacterial skin infections caused by MDR bacteria.

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