Researchers have demonstrated that antibiotic-resistance plasmids persist in the absence of antibiotics, provided that the efficiency of plasmid transfer exceeds a critical threshold, highlighting the limitations of ‘resistance-reversal’ strategies.
Browsing: Bacterial > E. Coli
Researchers have analyzed the microbiomes of flies, suggesting that these insects could have more disease-carrying potential than previously thought.
Researchers have unveiled novel pathways controlled by the multiple antibiotic resistance operon and identified new ways in which bacteria protect themselves against antibiotics.
In this infographic we summarize the clinical candidates reported by the WHO – indicating which diseases they are active (or possibly active) against, whether they’re considered innovative and which Phase the trials are currently in.
In this piece, the authors give an overview of anti-virulence drugs, designed to selectively target key virulence factors of pathogenic bacteria, and one strategy for new antimicrobials.
Scientists have unveiled the molecular architecture of two key proteins required for bacillus cell wall elongation. Inhibiting their interaction could provide a new mode of action for antibiotics against highly resistant bacteria.
A recently published study has uncovered how an antibiotic that targets a metabolic pathway to starve bacteria of a nutrient can lead to cell death, shedding light on the downstream effects that can account for toxicity.
Researchers have developed novel antimicrobials, such as metal-complexes, that could be used to treat infections – either as alternatives or supplements to traditional antibiotics – caused by multidrug-resistant bacteria.
Silver nanoparticles have long been used as potent antibacterial agents. However, toxicity concerns of silver nanoparticles have limited their successful clinical applications. This research reports a simple and cost-effective method for the synthesis of nickel-prussian blue@silver nanocomposites.
Julie Kaiser discusses the findings and implications of a recent study published in PNAS modeling the sequence of events that increases the risk of colonization and infection with multidrug-resistant (MDR) bacteria.