Resistance to Naphthoquine has been found in mouse models and might emerge in future as widely used. In this article, the in vivo antimalarial activity of novel naphthoquine derivatives is assessed revealing promising antimalarial candidates for further research.
Browsing: Parasitic > Malaria
Researchers have developed a microfluidic device that can assess the deformability of red blood cells and consequently haemolytic anemia. In future it could be used to monitor the disease progression of malaria.
In the first large-scale study of malaria gene function researchers identified that the parasite has a high proportion of essential genes, and have identified potential new targets for antimalarial drugs.
Researchers have discovered that the malaria parasite actively adapts to host calorie intake, identifying a nutrient-sensing enzyme that modulates the pathogen’s replication rate and virulence.
A new study has suggested that higher amounts of decaying infrastructure in lower socioeconomic neighborhoods may provide more breeding sites for mosquitoes, leaving residents vulnerable to mosquito-borne diseases.
Researchers have discovered a variation in the human red blood cell receptor glycophorin that appears to reduce the risk of severe malaria by 40%.
Study discovers that high levels of maternal microchimerism may directly affect the offspring’s immune system even after birth.
The recurring resistance of the malaria parasite to many drugs compels the design of innovative chemical entities in antimalarial research. In light of this, the authors discuss thiaheterocyclic hHDAC6 inhibitors as potentially powerful novel antimalarials.
In this systematic review from Future Microbiology the author assesses data of Phase I–III trials including malaria-naive adults and adults, children and infants from malaria endemic settings in sub-Saharan Africa.