The recurring resistance of the malaria parasite to many drugs compels the design of innovative chemical entities in antimalarial research. In light of this, the authors discuss thiaheterocyclic hHDAC6 inhibitors as potentially powerful novel antimalarials.
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In this systematic review from Future Microbiology the author assesses data of Phase I–III trials including malaria-naive adults and adults, children and infants from malaria endemic settings in sub-Saharan Africa.
To highlight World Malaria Day To highlight World Malaria Day take a look at our video infographic based on the WHO’s World Malaria Report.
Host gene expression patterns could be utilized to accurately diagnose malaria according to research presented at ECCMID 2017 on World Malaria Day.
Two proteins, crucial for enabling the cell traversal activity of malarial parasites, have been identified by a team of researchers who hope these could be targeted in drug or vaccine development.
In this editorial the authors discuss conventional diagnostic approaches and alternative diagnostic tests, which could be used in the future.
The National Institutes of Health (MD, USA) have begun a Phase I clinical trial examining a vaccine intended to provide broad protection against a range of mosquito-borne diseases by targeting the insect’s saliva.
Researchers have demonstrated that a new whole-parasite vaccine could provide up to 100% protection in clinical trials carried out at the University of Tübingen (Germany).
New research links clusters of virulence-associated pir genes in malaria parasites with their ability to persist in the body, sustaining transmission once symptoms have subsided.