Researchers have demonstrated that leishmania infection causes dysbiosis in the skin microbiota of both humans and mice. Moreover, in mice they discovered this dybiosis can be passed to naïve mice after close contact with infected individuals.
Browsing: Parasitic > Neglected Tropical Diseases
Chagas disease displays different parasitic stages, phases of disease and consequently special diagnostic needs, leading to underdiagnosis and further spread to non-endemic countries. Find out more in this exclusive piece.
It may be possible to interrupt the transmission of soil-transmitted helminths, which affect nearly 2 billion individuals globally. Here, the authors give an overview of the DeWorm3 project, which aims to test the feasibility of interrupting soil-transmitted helminth transmission.
In this interview, Roy Anderson, Director for the London Centre for Neglected Tropical Disease Research speaks about the work undertaken by the Centre and gives his thoughts on the wider NTD field.
As part of the authors ongoing research efforts dedicated to the discovery of novel cruzain inhibitors, a series of benzimidazole derivatives was used to develop predictive 2D and 3D quantitative structure–activity relationship (QSAR) models.
Martin Olivier, discusses how the nanobiome of vectors may impact the infectious processes of disease, highlighting his work on exosomes in sandflies and leishmaniasis.
Researchers have quantified the burden of stigmatization and discrimination on lymphatic filariasis patients, discovering individuals are up to four times more likely to suffer depression than average.
In this preliminary communication, the authors selected and characterized aptamers targeting the 5′-UTR from dengue virus, a sequence with important regulatory elements for its life cycle, with applications as potential antiviral and diagnostic tools.
Researchers have demonstrated that Trypanosoma brucei, the parasite responsible for sleeping sickness, has its own molecular clock, which could affect the parasite’s sensitivity to treatments.
Researchers have uncovered the role of inflammasome activation in leishmaniasis progression and severity, demonstrating that inhibiting these pathways may present a potential avenue for future treatments.