In this interview, Roy Anderson, Director for the London Centre for Neglected Tropical Disease Research speaks about the work undertaken by the Centre and gives his thoughts on the wider NTD field.
As part of the authors ongoing research efforts dedicated to the discovery of novel cruzain inhibitors, a series of benzimidazole derivatives was used to develop predictive 2D and 3D quantitative structure–activity relationship (QSAR) models.
Martin Olivier, discusses how the nanobiome of vectors may impact the infectious processes of disease, highlighting his work on exosomes in sandflies and leishmaniasis.
Researchers have quantified the burden of stigmatization and discrimination on lymphatic filariasis patients, discovering individuals are up to four times more likely to suffer depression than average.
In this preliminary communication, the authors selected and characterized aptamers targeting the 5′-UTR from dengue virus, a sequence with important regulatory elements for its life cycle, with applications as potential antiviral and diagnostic tools.
Researchers have demonstrated that Trypanosoma brucei, the parasite responsible for sleeping sickness, has its own molecular clock, which could affect the parasite’s sensitivity to treatments.
Researchers have uncovered the role of inflammasome activation in leishmaniasis progression and severity, demonstrating that inhibiting these pathways may present a potential avenue for future treatments.
In this interview, expert Robert Colebunders discusses his investigations into the potential parasitic cause of nodding syndrome, the prospects for preventing this neglected disorder in the future and the importance of multi-country and transdisciplinary studies.
In this study, the authors investigate the miRNA expression profile of Schistosoma japonicum in response to atesunate providing an overview of the complex mechanism.
Researchers have identified a crucial mechanism by which the chikungunya virus infects host cells and mediates disease severity. This could present a future treatment target for both chikungunya and related viruses.
