The largest genetic study of malaria parasites in Southeast Asia has revealed that resistance to the most powerful antimalarial drugs has been spreading unreported for years in Cambodia.
In this article, from Future Medicinal Chemistry, the researchers synthesize a new series of pyrazolo[1,5-c]pyrimidines via hybridization strategies and evaluate these for in vitro activity against leishmaniasis
Scientists have revealed proteins, termed RIFINs, expressed on the surface of infected erythrocytes that may help the malaria parasite to suppress the host immune response, leading to severe infection.
For the first time researchers have cloned and characterized NANP-reactive memory B-cell antibodies in humans, which have the ability to potently inhibit parasite transmission in vivo.
Researchers have carried out the largest genetic study of Anopheles gambiae, discovering the spread of resistance and high genetic diversity.
November sees the release of the World Malaria Report, and here we take a look at the key facts and figures.
Researchers have discovered endemic malaria infection in a geographically-restricted set of wild bonobos, including a possible new species of the parasite.
Researchers have discovered that individuals infected with malaria exhale specific compounds, which could be used to rapidly and accurately diagnose the disease.
Researchers have uncovered five new targets for malaria vaccine development, suggesting that targeting multiple steps of erythrocyte invasion is more likely to produce an effective vaccine.
The spread of a single multi-drug resistant Plasmodium falciparum lineage to south Vietnam has caused alarm after worrying treatment failure rates. Researchers suggest this presents a serious concern for malaria control efforts.
