Resistance to Naphthoquine has been found in mouse models and might emerge in future as widely used. In this article, the in vivo antimalarial activity of novel naphthoquine derivatives is assessed revealing promising antimalarial candidates for further research.
Researchers have developed a microfluidic device that can assess the deformability of red blood cells and consequently haemolytic anemia. In future it could be used to monitor the disease progression of malaria.
In the first large-scale study of malaria gene function researchers identified that the parasite has a high proportion of essential genes, and have identified potential new targets for antimalarial drugs.
Researchers have discovered that the malaria parasite actively adapts to host calorie intake, identifying a nutrient-sensing enzyme that modulates the pathogen’s replication rate and virulence.
In this review, the authors discuss recent findings on unfolded protein response (UPR) induction/modulation by intracellular parasites in host cells.
Researchers have discovered a variation in the human red blood cell receptor glycophorin that appears to reduce the risk of severe malaria by 40%.
In this systematic review from Future Microbiology the author assesses data of Phase I–III trials including malaria-naive adults and adults, children and infants from malaria endemic settings in sub-Saharan Africa.
To highlight World Malaria Day To highlight World Malaria Day take a look at our video infographic based on the WHO’s World Malaria Report.
Host gene expression patterns could be utilized to accurately diagnose malaria according to research presented at ECCMID 2017 on World Malaria Day.
Two proteins, crucial for enabling the cell traversal activity of malarial parasites, have been identified by a team of researchers who hope these could be targeted in drug or vaccine development.
