Recent technological advancements have allowed organoids to become a viable research tool for a wide range of development and disease models. Here, we look at some of the research that’s been done in infectious diseases and delve into what the future of organoids might look like.
Browsing: Parasitic > Protozoan Infections
A new study has estimated that up to 30% of parasite burden could be in the liver and bone marrow of infected individuals, a reservoir that has previously gone undetected and unstudied.
The largest genetic study of malaria parasites in Southeast Asia has revealed that resistance to the most powerful antimalarial drugs has been spreading unreported for years in Cambodia.
In this article, from Future Medicinal Chemistry, the researchers synthesize a new series of pyrazolo[1,5-c]pyrimidines via hybridization strategies and evaluate these for in vitro activity against leishmaniasis
Scientists have revealed proteins, termed RIFINs, expressed on the surface of infected erythrocytes that may help the malaria parasite to suppress the host immune response, leading to severe infection.
For the first time researchers have cloned and characterized NANP-reactive memory B-cell antibodies in humans, which have the ability to potently inhibit parasite transmission in vivo.
Researchers have carried out the largest genetic study of Anopheles gambiae, discovering the spread of resistance and high genetic diversity.
Researchers have discovered endemic malaria infection in a geographically-restricted set of wild bonobos, including a possible new species of the parasite.
Researchers have discovered that individuals infected with malaria exhale specific compounds, which could be used to rapidly and accurately diagnose the disease.