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Researchers use CRISPR gene editing to uncover potential HIV treatments
Using CRISPR researchers have identified 86 genes that could be associated with HIV replication and disease, opening doors to research…
Browsing: Basic > Drug Development
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Novel stem-cell transplants could be an HIV cure
The first female, nonwhite and HIV-positive cancer patient treated with a new stem-cell transplant therapy is now in long-term remission…
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DNA-encoded immunogens: the next step forward in HIV vaccine research
Researchers demonstrate the value of nucleic acid technology in encoding immunogens capable of eliciting tier-2 neutralizing antibodies against HIV in the race to develop…
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Experimental enzyme shows promise as a prophylaxis to anthrax spores
Sometimes in experimental biology the very factor that is part of the disease-causing mechanism can also be the factor that…
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Hope for HIV: mRNA vaccine displays encouraging results in animal studies
A new mRNA HIV vaccine technology encodes key proteins to form virus-like particles (VLPs) that induce neutralizing antibodies safely and effectively in animal studies with minimal side effects. Researchers from…
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Oteseconazole: an advance in treatment of recurrent vulvovaginal candidiasis
This review, recently published in our partner journal Future Microbiology, discusses the pharmacology of oteseconazole and summarizes clinical studies investigating…
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Whole-cell vaccines reimagined: a new method against recurrent UTI?
New encapsulating technology for whole-cell vaccines stimulates enhanced immunogenicity against Escherichia coli in a mouse model, shaping the future of urinary tract infection (UTI) vaccines. Recurrent…
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Drugs from nature: ethnobotany as a strategy for antimicrobial drug discovery
Plant natural products represent a largely untapped resource for discovering bioactive compounds to fill the antimicrobial drug development pipeline. With…
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Turning the tide on malaria: WHO approves the world’s first vaccine
A historic moment: WHO recommends deployment of a malaria vaccine finally developed after a 100-year endeavour. The WHO have advised that the RTS,S/AS01 vaccine, also known as Mosquirix, developed by GlaxoSmithKline (London, England) over the last 30 years in…
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Bacteriophage ‘Muddy’ buddies up with antibiotic to combat antibiotic resistance
Researchers discover bacteriophage ‘Muddy’ and antibiotic rifabutin as a new dynamic duo combination therapy against antibiotic-resistant Mycobacterium abscessus infection in a cystic fibrosis zebrafish model. A group of researchers…