Resistance to Naphthoquine has been found in mouse models and might emerge in future as widely used. In this article, the in vivo antimalarial activity of novel naphthoquine derivatives is assessed revealing promising antimalarial candidates for further research.
Browsing: Basic > Drug Development
In this piece, Fabio Gsaller discusses the mechanisms underpinning antifungal resistance in A. fumigatus and his work on the use of 5-flucytosine as a therapeutic agent in managing aspergillosis.
Researchers have discovered that some oligosaccharides from human breast milk may possess antimicrobial and anti-biofilm properties against Group B Streptococcus (GBS).
Researchers have uncovered a therapeutic delivery method for nitric oxide in the treatment of dermal Trichophyton rubrum dermatophytosis; providing an alternative treatment to the systemic therapies currently used.
In this review the authors discuss evidences suggesting that bacterial zinc homeostasis represents a promising target for new antimicrobial strategies, focusing on the inhibition of zinc uptake in Salmonella enterica.
Interval dosing with Vorinostat could reverse HIV latency, however, additional measures are still required to achieve complete HIV reservoir depletion, study suggests.
In the first large-scale study of malaria gene function researchers identified that the parasite has a high proportion of essential genes, and have identified potential new targets for antimalarial drugs.
Researchers have identified the primary enzymatic source of reactive oxygen species in humans, discovering that this enzyme exacerbates viral pathogenicity and suggesting that it could be an antiviral target.
Recently, the use of small molecules produced by bacteria became a prominent strategy of biofilm dispersal. Here, the authors discuss small molecules that interfere with biofilm formation, focusing on the complex mode of action and applications of D-amino acids.