Browsing: Basic > Drug Development
Researchers have uncovered a therapeutic delivery method for nitric oxide in the treatment of dermal Trichophyton rubrum dermatophytosis; providing an alternative treatment to the systemic therapies currently used.
In this review the authors discuss evidences suggesting that bacterial zinc homeostasis represents a promising target for new antimicrobial strategies, focusing on the inhibition of zinc uptake in Salmonella enterica.
Interval dosing with Vorinostat could reverse HIV latency, however, additional measures are still required to achieve complete HIV reservoir depletion, study suggests.
In the first large-scale study of malaria gene function researchers identified that the parasite has a high proportion of essential genes, and have identified potential new targets for antimalarial drugs.
Researchers have identified the primary enzymatic source of reactive oxygen species in humans, discovering that this enzyme exacerbates viral pathogenicity and suggesting that it could be an antiviral target.
Recently, the use of small molecules produced by bacteria became a prominent strategy of biofilm dispersal. Here, the authors discuss small molecules that interfere with biofilm formation, focusing on the complex mode of action and applications of D-amino acids.
After the WHO published data highlighting a concerning level of antibiotic resistance in strains of gonorrhoea, take a closer look at the three antibiotics currently in clinical trials for this pathogen.
The WHO has reported increasing drug resistance in gonorrhoea, with some cases untreatable by current antibiotics, and stated that new drugs are urgently required.
Researchers have discovered that the malaria parasite actively adapts to host calorie intake, identifying a nutrient-sensing enzyme that modulates the pathogen’s replication rate and virulence.