0 New antibiotic shows promise against gonorrhoea
An antibiotic, closthioamide, has been demonstrated to have high anti-gonococcal activity in vitro including against drug-resistant strains, highlighting this as a promising drug prospect.
Browsing: Basic > Drug Development
0 Topical nitric oxide-releasing nanoparticles could be a treatment for dermal dermatophytosis
Researchers have uncovered a therapeutic delivery method for nitric oxide in the treatment of dermal Trichophyton rubrum dermatophytosis; providing an alternative treatment to the systemic therapies currently used.
0 A novel antimicrobial approach based on the inhibition of zinc uptake in Salmonella enterica
In this review the authors discuss evidences suggesting that bacterial zinc homeostasis represents a promising target for new antimicrobial strategies, focusing on the inhibition of zinc uptake in Salmonella enterica.
0 How can interval dosing with Vorinostat reverse HIV latency?
Interval dosing with Vorinostat could reverse HIV latency, however, additional measures are still required to achieve complete HIV reservoir depletion, study suggests.
0 First large-scale study uncovers malaria gene function and potential drug targets
In the first large-scale study of malaria gene function researchers identified that the parasite has a high proportion of essential genes, and have identified potential new targets for antimalarial drugs.
0 Could targeting ROS enzyme provide a broad antiviral strategy?
Researchers have identified the primary enzymatic source of reactive oxygen species in humans, discovering that this enzyme exacerbates viral pathogenicity and suggesting that it could be an antiviral target.
0 Beyond the wall: can D-amino acids and small molecule inhibitors eliminate infections?
Recently, the use of small molecules produced by bacteria became a prominent strategy of biofilm dispersal. Here, the authors discuss small molecules that interfere with biofilm formation, focusing on the complex mode of action and applications of D-amino acids.
0 Gonorrhoea – the current antibiotic pipeline and the need for new drugs
After the WHO published data highlighting a concerning level of antibiotic resistance in strains of gonorrhoea, take a closer look at the three antibiotics currently in clinical trials for this pathogen.
0 WHO highlights concerning drug resistance in gonorrhoea
The WHO has reported increasing drug resistance in gonorrhoea, with some cases untreatable by current antibiotics, and stated that new drugs are urgently required.
2 Malaria parasite adapts to host’s nutritional status
Researchers have discovered that the malaria parasite actively adapts to host calorie intake, identifying a nutrient-sensing enzyme that modulates the pathogen’s replication rate and virulence.
