In this editorial the authors discuss how targeting the human TREX complex could prevent herpesvirus replication, highlighting their own work targeting herpesvirus lytic replication through inhibition of the hTREX complex.
Browsing: Basic > Drug Development
Oral delivery of vaccines is an attractive approach but is hampered by a number of challenges. Here, the authors discuss the need to include immunostimulatory adjuvants in oral vaccines to overcome oral tolerance and elicit effector immune responses locally within the intestine.
This editorial presents some of the latest evidence to support the antivirulence approach, highlighting at the same time some of the issues that need to be considered when evaluating antivirulence drugs.
In this podcast Dr Elizabeth Whittaker, Dr James Seddon, Dr Pete Dodd and Professor Beate Kampmann discuss their work in pediatric tuberculosis focusing on the areas of immunology, modelling and drug resistance.
Take a look at our new infographic, developed for World Tuberculosis Day, which explores the facts about current TB burden, the issues around drug resistance, and research and development moving forwards.
In this original research article, the authors determine the structural contributions of a compound set containing inhibitors of bacterial enzyme FabI.