Researchers have identified the primary enzymatic source of reactive oxygen species in humans, discovering that this enzyme exacerbates viral pathogenicity and suggesting that it could be an antiviral target.
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Researchers have gained new insights into the role of human guanylate-binding protein 1 (hGBP1) in pathogen response, uncovering a role in membrane tethering.
Researchers have demonstrated that leishmania infection causes dysbiosis in the skin microbiota of both humans and mice. Moreover, in mice they discovered this dybiosis can be passed to naïve mice after close contact with infected individuals.
Researchers have identified a subpopulation of T cells as key cytokine producers in addition to proposing a novel mechanism of immunosuppression following superantigen exposure.
Improved therapeutic strategies are in urgent need for better control and eradication of tuberculosis. In this editorial, the authors evaluate interleukin-37 as a new molecular target for the therapy of tuberculosis.
Research presented at ASM Microbe has reported a Zika vaccine based on the NS1 protein can induce protective immunity in mouse models after a single dose.
Researchers have discovered that compounds altering transmembrane potential in Xenopus laevis may improve resistance to E. coli infection.
Helen McShane discusses her work leading the TB vaccine research program at Oxford University, and shares her thoughts on the challenges facing vaccine development and eradication of this disease.
Study discovers that high levels of maternal microchimerism may directly affect the offspring’s immune system even after birth.