For the first time, physicists have created a 3D movie that demonstrates a virus preparing to infect a healthy cell via genomic rearrangement – leading to the potential to better treat an array of human diseases caused by viruses.
Browsing: Basic > Molecular biology
The use of biomarkers for the detection of fungal infections is of interest to complement histopathological and culture methods. Could chemically synthesized Galactofuranose antigens, reviewed in this paper, be used for the synthesis of artificial carbohydrate-based antigens and in diagnosis?
Researchers have gained new insights into the role of human guanylate-binding protein 1 (hGBP1) in pathogen response, uncovering a role in membrane tethering.
Researchers have developed a potential new treatment strategy for gonorrhoea that targets the enzyme needed for the bacterium to respire anaerobically in its oxygen-poor biofilm environment.
Chagas disease displays different parasitic stages, phases of disease and consequently special diagnostic needs, leading to underdiagnosis and further spread to non-endemic countries. Find out more in this exclusive piece.
Researchers have discovered sequence-specific interactions between hepatitis B proteins and pre-genome RNA that may play a crucial role in nucleocapsid assembly. This could be targeted in future drug development.
Researchers have reported a small-molecule inhibitor of Candida albican protein Bdf1 and demonstrated the compound yields decreased fungal viability, suggesting a possible future antifungal.
As part of the authors ongoing research efforts dedicated to the discovery of novel cruzain inhibitors, a series of benzimidazole derivatives was used to develop predictive 2D and 3D quantitative structure–activity relationship (QSAR) models.