Researchers have discovered sequence-specific interactions between hepatitis B proteins and pre-genome RNA that may play a crucial role in nucleocapsid assembly. This could be targeted in future drug development.
Researchers have reported a small-molecule inhibitor of Candida albican protein Bdf1 and demonstrated the compound yields decreased fungal viability, suggesting a possible future antifungal.
As part of the authors ongoing research efforts dedicated to the discovery of novel cruzain inhibitors, a series of benzimidazole derivatives was used to develop predictive 2D and 3D quantitative structure–activity relationship (QSAR) models.
Researchers investigating Ebola virus have uncovered the function of delta protein, which is released in high levels during infection, and findings suggest it could play a crucial role in disease pathology.
In this exclusive piece the authors discuss the choice of peptide antigen, delivery system/adjuvant and delivery route as key factors in the development of an effective human vaccine against group A Streptococcus.
Researchers have uncovered structural and functional details of a key Lassa virus protein; this new information may aid the development of vaccines and therapeutics in the future.
A team from the Scripps Research Institute have determined the structure of clade C HIV-1 envelope glycoprotein, an immunogen that could be utilized in a future HIV vaccine.
Researchers have discovered that compounds altering transmembrane potential in Xenopus laevis may improve resistance to E. coli infection.
Author, Khaled Barakat, argues that computational modeling has a great potential in directing hepatitis research, to understand the liver and to discover better and more effective treatments.
In this preliminary communication, the authors selected and characterized aptamers targeting the 5′-UTR from dengue virus, a sequence with important regulatory elements for its life cycle, with applications as potential antiviral and diagnostic tools.
