Researchers have developed a potential new treatment strategy for gonorrhoea that targets the enzyme needed for the bacterium to respire anaerobically in its oxygen-poor biofilm environment.
Browsing: Basic > Molecular biology
Chagas disease displays different parasitic stages, phases of disease and consequently special diagnostic needs, leading to underdiagnosis and further spread to non-endemic countries. Find out more in this exclusive piece.
Researchers have discovered sequence-specific interactions between hepatitis B proteins and pre-genome RNA that may play a crucial role in nucleocapsid assembly. This could be targeted in future drug development.
Researchers have reported a small-molecule inhibitor of Candida albican protein Bdf1 and demonstrated the compound yields decreased fungal viability, suggesting a possible future antifungal.
As part of the authors ongoing research efforts dedicated to the discovery of novel cruzain inhibitors, a series of benzimidazole derivatives was used to develop predictive 2D and 3D quantitative structure–activity relationship (QSAR) models.
In this exclusive piece the authors discuss the choice of peptide antigen, delivery system/adjuvant and delivery route as key factors in the development of an effective human vaccine against group A Streptococcus.
A team from the Scripps Research Institute have determined the structure of clade C HIV-1 envelope glycoprotein, an immunogen that could be utilized in a future HIV vaccine.
Researchers have discovered that compounds altering transmembrane potential in Xenopus laevis may improve resistance to E. coli infection.