Resistance to Naphthoquine has been found in mouse models and might emerge in future as widely used. In this article, the in vivo antimalarial activity of novel naphthoquine derivatives is assessed revealing promising antimalarial candidates for further research.
Browsing: Clinical > Antimicrobial Resistance
In this piece, Fabio Gsaller discusses the mechanisms underpinning antifungal resistance in A. fumigatus and his work on the use of 5-flucytosine as a therapeutic agent in managing aspergillosis.
In this interview, we speak to Cornelia Lass-Flörl from the Innsbruck Medical University (Austria) who has a special interest in the epidemiology, diagnosis, prevention and therapy of fungal infections.
In this IDHTalks podcast we speak to Mahmoud Ghannoum about the importance of fungi, his work in identifying mycobiome and its implications in health and disease.
Researchers have demonstrated that the efficacy of phage therapy is dependent on synergy with the host’s immune system.
Currently, carbapenems are an antibiotic option against MDR K. pneumoniae worldwide, however, carbapenem resistance is being reported on a large scale. This study investigates the mechanism leading to in vivo carbapenem resistance development in Klebsiella pneumoniae.
Several recent papers have investigated how polymicrobial interactions in the cystic fibrosis (CF) lung influence antimicrobial efficacy, demonstrating that microbial metabolites produced by one pathogen can alter the antimicrobial killing of another pathogen.
A new analysis has suggested that the notion of ‘completing the course’ when taking antibiotics is not evidence-based and should be dropped as it may actually increase the risk of antibiotic resistance.