Virtual screening (VS) is powerful tool in discovering molecular inhibitors that are most likely to bind to drug targets of interest. Here, the authors introduce a novel VS approach, so-called ‘tailored-pharmacophore’, in order to explore inhibitors that overcome drug resistance.
Browsing: Clinical > Antimicrobial Resistance
Researchers have successfully treated a 68-year old diabetic patient with a personalized bacteriophage-based treatment. The patient suffered from necrotizing pancreatitis that had previously been unresponsive to routine antibiotic treatment.
Resistance to Naphthoquine has been found in mouse models and might emerge in future as widely used. In this article, the in vivo antimalarial activity of novel naphthoquine derivatives is assessed revealing promising antimalarial candidates for further research.
Inappropriate use and overuse of antibiotics are among the most important factors in resistance development, and effective antibiotic stewardship measures are needed to optimize outcomes.
In this piece, Fabio Gsaller discusses the mechanisms underpinning antifungal resistance in A. fumigatus and his work on the use of 5-flucytosine as a therapeutic agent in managing aspergillosis.
In this interview, we speak to Cornelia Lass-Flörl from the Innsbruck Medical University (Austria) who has a special interest in the epidemiology, diagnosis, prevention and therapy of fungal infections.
In this IDHTalks podcast we speak to Mahmoud Ghannoum about the importance of fungi, his work in identifying mycobiome and its implications in health and disease.
Researchers have demonstrated that the efficacy of phage therapy is dependent on synergy with the host’s immune system.