In this review, the authors discuss recent findings on unfolded protein response (UPR) induction/modulation by intracellular parasites in host cells.
As part of the authors ongoing research efforts dedicated to the discovery of novel cruzain inhibitors, a series of benzimidazole derivatives was used to develop predictive 2D and 3D quantitative structure–activity relationship (QSAR) models.
Improved therapeutic strategies are in urgent need for better control and eradication of tuberculosis. In this editorial, the authors evaluate interleukin-37 as a new molecular target for the therapy of tuberculosis.
The human papillomavirus (HPV) vaccine has recently attracted considerable attention in emerging countries. In this research article, the authors carry out a multi-country case study investigating the the adoption and use of HPV vaccines.
Resistance to β-lactams is an increasing problem. This review outlines various approaches taken to discover MBL inhibitors, with an emphasis on the different chemical classes of inhibitors.
This review aims to provide a better understanding of HEV71 virology and potential antivirals for progressive clinical development with respect to their elucidated mechanistic actions.
In this preliminary communication, the authors selected and characterized aptamers targeting the 5′-UTR from dengue virus, a sequence with important regulatory elements for its life cycle, with applications as potential antiviral and diagnostic tools.
The lack of viable antibiotics has urged researchers to think of new approaches to treat deadly bacterial infections. This editorial discusses the progress so far, and the future applications, of strategies involving predatory bacteria.
Antivirulence agents represent an attractive alternative to antibiotics. Here, the authors discuss the advantages, and the gaps in antivirulence therapy.