Resistance to Naphthoquine has been found in mouse models and might emerge in future as widely used. In this article, the in vivo antimalarial activity of novel naphthoquine derivatives is assessed revealing promising antimalarial candidates for further research.
Inappropriate use and overuse of antibiotics are among the most important factors in resistance development, and effective antibiotic stewardship measures are needed to optimize outcomes.
The pathogenicity of T. marneffei depends on the ability of the fungus to survive the killing process and replicate inside the host macrophage cells. This paper summarizes factors relating to the stress responses that contribute to the intracellular survival of T. marneffei
This study characterizes 23 nonserotypeable Shigella using whole genome sequencing, discovering this approach for Shigella O-antigen analysis has greater discriminative power than other methods using different bioinformatics pipeline for identification of nonserotypeable Shigella.
Currently, carbapenems are an antibiotic option against MDR K. pneumoniae worldwide, however, carbapenem resistance is being reported on a large scale. This study investigates the mechanism leading to in vivo carbapenem resistance development in Klebsiella pneumoniae.
Weight cycling has been suggested to have detrimental effects on energy homeostasis and other metabolic pathologies, but the mechanisms initially driving this phenomenon remain to be fully elucidated – here the authors discuss the role of the microbiome.
In this review the authors discuss evidences suggesting that bacterial zinc homeostasis represents a promising target for new antimicrobial strategies, focusing on the inhibition of zinc uptake in Salmonella enterica.
In this editorial, the authors dicuss how mobile phones have the potential to transform traditional uses of imaging, sensing and diagnostic systems, especially for point-of-care applications and field settings.
Recently, the use of small molecules produced by bacteria became a prominent strategy of biofilm dispersal. Here, the authors discuss small molecules that interfere with biofilm formation, focusing on the complex mode of action and applications of D-amino acids.
The use of biomarkers for the detection of fungal infections is of interest to complement histopathological and culture methods. Could chemically synthesized Galactofuranose antigens, reviewed in this paper, be used for the synthesis of artificial carbohydrate-based antigens and in diagnosis?