Prions are transmissible agents composed of aggregates of misfolded cellular prion protein (PrP) that cause fatal neurodegenerative diseases. Here the authors looks into what genomics can tell us about prion diseases, and gives a perspective on future needs.
In this editorial the authors offer a perspective about issues surrounding the implementation of molecular antibiograms in the diagnostic workflow.
The recurring resistance of the malaria parasite to many drugs compels the design of innovative chemical entities in antimalarial research. In light of this, the authors discuss thiaheterocyclic hHDAC6 inhibitors as potentially powerful novel antimalarials.
In this systematic review from Future Microbiology the author assesses data of Phase I–III trials including malaria-naive adults and adults, children and infants from malaria endemic settings in sub-Saharan Africa.
This Editorial discusses a Health Economics and Outcomes Research (HEOR) approach to use a formal comparative effectiveness analysis and a network meta-analysis for both first- and second-line ART regimens for adults, adolescents and children.
Given the ability of the microbiota to instruct the immune system and control the inflammatory response, the authors discuss the potential of targeting the microbiota to improve the immune recovery and dampen inflammation during HIV infection.
In this editorial the authors discuss how targeting the human TREX complex could prevent herpesvirus replication, highlighting their own work targeting herpesvirus lytic replication through inhibition of the hTREX complex.
Processing of the samples in molecular diagnostics is complex and labor-intensive. Here, the authors present a prototype of a versatile and integrated platform for the detection of pathogens in various liquid media.
This study delves aims to evaluate the efficacy of durancin 61A as an inhibitor of resistant clinical pathogens and to shed light on its mode of action.
Although understanding of Ebola virus pathogenesis has rapidly increased recently, many questions relating to the role of the vascular system remain unanswered. The authors here discuss how Ebola virus infection can cause endothelial dysfunction and coagulopathy.