Researchers have demonstrated that antibiotic-resistance plasmids persist in the absence of antibiotics, provided that the efficiency of plasmid transfer exceeds a critical threshold, highlighting the limitations of ‘resistance-reversal’ strategies.
To date there have only been a handful of Phase III efficacy trials for HIV vaccine candidates, which have had varied, and in some cases controversial, results. Here we review the history of HIV vaccine efficacy studies and look into the vaccine candidates closest to front-line use.
In this piece, the authors give an overview of anti-virulence drugs, designed to selectively target key virulence factors of pathogenic bacteria, and one strategy for new antimicrobials.
Using live predatory bacteria as an alternative to traditional antibiotics had been suggested and studied over the last several years. Here we discuss some aspects of predatory bacteria that highlight their potential to serve as a possible antibiotic in the future.
A recently published study has uncovered how an antibiotic that targets a metabolic pathway to starve bacteria of a nutrient can lead to cell death, shedding light on the downstream effects that can account for toxicity.
In our latest piece, Janet Daly discusses the species jump of influenza A virus from horses to dogs and the insights this gives into the factors involved in interspecies transmission events.