An antibiotic, closthioamide, has been demonstrated to have high anti-gonococcal activity in vitro including against drug-resistant strains, highlighting this as a promising drug prospect.
In this review the authors discuss evidences suggesting that bacterial zinc homeostasis represents a promising target for new antimicrobial strategies, focusing on the inhibition of zinc uptake in Salmonella enterica.
After the WHO published data highlighting a concerning level of antibiotic resistance in strains of gonorrhoea, take a closer look at the three antibiotics currently in clinical trials for this pathogen.
The WHO has reported increasing drug resistance in gonorrhoea, with some cases untreatable by current antibiotics, and stated that new drugs are urgently required.
Resistance to β-lactams is an increasing problem. This review outlines various approaches taken to discover MBL inhibitors, with an emphasis on the different chemical classes of inhibitors.
The lack of viable antibiotics has urged researchers to think of new approaches to treat deadly bacterial infections. This editorial discusses the progress so far, and the future applications, of strategies involving predatory bacteria.
Antivirulence agents represent an attractive alternative to antibiotics. Here, the authors discuss the advantages, and the gaps in antivirulence therapy.
Inhibition of MRSA and of Clostridium difficile by durancin 61A: synergy with bacteriocins and antibiotics
This study delves aims to evaluate the efficacy of durancin 61A as an inhibitor of resistant clinical pathogens and to shed light on its mode of action.
Ruth Neale talks us through the final day of the inaugural SDRI conference, including session overviews and the newly identified key priorities for antimicrobial resistance.