Competence-inhibiting drugs may prevent the spread of antibiotic resistance
Novel research suggests that some drugs may prevent the acquisition of resistance genes by preventing the induction of bacterial ‘competence’.
Browsing: Antimicrobial Resistance
Does drug tolerance promote antibiotic resistance despite combination therapy?
When investigating the effect tolerance to a single drug has when combination therapy is being used to prevent antibiotic resistance, a team of researchers demonstrated that antimicrobial tolerance can promote resistance.
New CRISPR editing technology targets antibiotic resistance plasmids
A team from the University of California, San Diego have created a new CRISPR editing system that can effectively target antibiotic resistance genes. The system is based on a positive feedback loop and has numerous potential applications, such as treating chronic bacterial infections.
Highlights of the CDC’s 2019 antibiotic resistance threats report
The CDC has released an updated report outlining the burden of antimicrobial resistance in the USA and the greatest threats that face this country.
Bacteriophage: alternative medicine or an evidence-based alternative?
Bacteriophage have been touted as the solution for antibiotic resistant microbes, why are they not being used in mainstream medicine?
Could game theory be used to predict antibiotic resistance genes?
Researchers have developed a game theory approach and a machine learning algorithm to accurately identify antibiotic resistance genes in bacteria.
Bacteria can lose cell walls in order to resist antibiotics
Researchers have observed a bacterial mechanism that allows bacteria to change form and resist antibiotics, without the transfer of resistance genes.
Combating resistance while maintaining innovation: The future of antimicrobial stewardship
In this perspective piece for Future Microbiology the authors argue that there is a lack of innovation to meet the current shortcomings of antibiotic R&D.
Multidrug efflux systems: information on evolution and mechanisms uncovered
Researchers have discovered that a relatively ancient drug efflux pump from Haemophilus influenzae exports the same antibiotics as its evolved counterpart from Escherichia coli, but was mitigated by a leaky porin channel.
A peek behind the paper – Sidharth Chopra on drug repurposing to tackle antimicrobial resistance
Take a look behind the scenes of a recent Future Microbiology review, entitled ‘An update on drug repurposing: Is it useful for tacking antimicrobial resistance?’ as we ask the authors about what challenges and limitations drug repurposing faces, in addition to why this strategy could be a promising alternative to the traditional drug discovery pipeline.
