Antimicrobials: handle with care
World Antimicrobial Awareness Week 2020 (WAAW; 18–24 November) is upon us. Infectious Diseases Hub takes…
Browsing: Antimicrobial Resistance
The importance of bacteriophage collections – an interview with Juandem Agendia and Sarah Alexander
In this podcast, Juandem Agendia and Sarah Alexander (NCTC, UK) discuss bacteriophages, the function of…
Infographic: Tackling antimicrobial resistance with phages
Phages are a promising alternative to antibiotics, especially considering the looming increase in multidrug-resistant bacteria.…
The role of home and the community hygiene to prevent the spread of infection and reduce antimicrobial resistance in developed countries
Exploring the evidence to support the role of home and community hygiene in preventing the…
Application of bacteriophages to overcome antimicrobial resistance
Bacteriophages (viruses that invade bacteria and can kill them) have gained renewed interest as part…
Could RBX2660 be the microbiome-based solution to C. diff infection recurrence?
Rebiotix (MN, USA) recently announced positive preliminary results from an ongoing clinical trial investigating the use of an investigational microbiota-based formulation, RBX2660, for the reduction of C. diff infection.
Resistance-free ‘poisoned arrow’ antibiotic kills Gram-negative bacteria
Researchers from Princeton University have uncovered an antibiotic molecule capable of killing both Gram-negative and Gram-positive bacteria using two simultaneous mechanisms, while also avoiding antibiotic resistance.
Competence-inhibiting drugs may prevent the spread of antibiotic resistance
Novel research suggests that some drugs may prevent the acquisition of resistance genes by preventing the induction of bacterial ‘competence’.
Does drug tolerance promote antibiotic resistance despite combination therapy?
When investigating the effect tolerance to a single drug has when combination therapy is being used to prevent antibiotic resistance, a team of researchers demonstrated that antimicrobial tolerance can promote resistance.
New CRISPR editing technology targets antibiotic resistance plasmids
A team from the University of California, San Diego have created a new CRISPR editing system that can effectively target antibiotic resistance genes. The system is based on a positive feedback loop and has numerous potential applications, such as treating chronic bacterial infections.