When investigating the effect tolerance to a single drug has when combination therapy is being used to prevent antibiotic resistance, a team of researchers demonstrated that antimicrobial tolerance can promote resistance.
A team from the University of California, San Diego have created a new CRISPR editing system that can effectively target antibiotic resistance genes. The system is based on a positive feedback loop and has numerous potential applications, such as treating chronic bacterial infections.
The CDC has released an updated report outlining the burden of antimicrobial resistance in the USA and the greatest threats that face this country.
Bacteriophage have been touted as the solution for antibiotic resistant microbes, why are they not being used in mainstream medicine?
Researchers have developed a game theory approach and a machine learning algorithm to accurately identify antibiotic resistance genes in bacteria.
Researchers have observed a bacterial mechanism that allows bacteria to change form and resist antibiotics, without the transfer of resistance genes.
In this perspective piece for Future Microbiology the authors argue that there is a lack of innovation to meet the current shortcomings of antibiotic R&D.
Researchers have discovered that a relatively ancient drug efflux pump from Haemophilus influenzae exports the same antibiotics as its evolved counterpart from Escherichia coli, but was mitigated by a leaky porin channel.
Take a look behind the scenes of a recent Future Microbiology review, entitled ‘An update on drug repurposing: Is it useful for tacking antimicrobial resistance?’ as we ask the authors about what challenges and limitations drug repurposing faces, in addition to why this strategy could be a promising alternative to the traditional drug discovery pipeline.
Coagulation factors, which normally function to clot blood, have been demonstrated to have antibacterial action against Gram-negative bacteria in vitro and in mouse models.
