Could game theory be used to predict antibiotic resistance genes?
Researchers have developed a game theory approach and a machine learning algorithm to accurately identify antibiotic resistance genes in bacteria.
Browsing: Antimicrobial Resistance
Bacteria can lose cell walls in order to resist antibiotics
Researchers have observed a bacterial mechanism that allows bacteria to change form and resist antibiotics, without the transfer of resistance genes.
Combating resistance while maintaining innovation: The future of antimicrobial stewardship
In this perspective piece for Future Microbiology the authors argue that there is a lack of innovation to meet the current shortcomings of antibiotic R&D.
Multidrug efflux systems: information on evolution and mechanisms uncovered
Researchers have discovered that a relatively ancient drug efflux pump from Haemophilus influenzae exports the same antibiotics as its evolved counterpart from Escherichia coli, but was mitigated by a leaky porin channel.
A peek behind the paper – Sidharth Chopra on drug repurposing to tackle antimicrobial resistance
Take a look behind the scenes of a recent Future Microbiology review, entitled ‘An update on drug repurposing: Is it useful for tacking antimicrobial resistance?’ as we ask the authors about what challenges and limitations drug repurposing faces, in addition to why this strategy could be a promising alternative to the traditional drug discovery pipeline.
Coagulation factors show activity against drug-resistant Gram-negative bacteria
Coagulation factors, which normally function to clot blood, have been demonstrated to have antibacterial action against Gram-negative bacteria in vitro and in mouse models.
Malaria: genomic surveillance detects multi-drug resistance has spread in Asia
Multidrug resistance to two antimalarials, used in combination as a first-line therapy, has been found using genomic surveillance to be rapidly spreading throughout Asia.
Infographic: Gonorrhea – a timeline of resistance and it’s mechanisms
In this infographic we give you a visual snapshot of the antibiotics introduced for gonorrhea and a timeline of when resistance was first identified, in addition to setting out some of the primary resistance mechanisms.
ASM Microbe: Sustained transmission of resistant bacterial strain detected in hospital for over 3 years
A team of researchers have demonstrated the transmission of a single bacterial strain that possessed a carbapenem-resistance gene, using whole-genome sequencing.
ASM Microbe: Cannabidiol found to be active against Gram-positive bacteria
An in vitro study has identified potent antibiotic properties possessed by cannabidiol, discovering activity against Gram-positive bacteria such as Staphylococcus aureus and Streptococcus pneumoniae.
