In this exclusive piece the authors discuss the choice of peptide antigen, delivery system/adjuvant and delivery route as key factors in the development of an effective human vaccine against group A Streptococcus.
Browsing: Bacterial Protein
Studies of Staphylococcus aureus FabI inhibitors: fragment-based approach based on holographic structure–activity relationship analyses
In this original research article, the authors determine the structural contributions of a compound set containing inhibitors of bacterial enzyme FabI.
Researchers have discovered that a component of the Staphylococcus aureus cell wall appears to be responsible for elevated virulence in community-associated MRSA infections. This mechanism could present a target for novel anti-infective strategies.