Phage therapy: two paths to approval
Discover more about the two routes phage therapy could take, the standardized drug approach and the personalized medicine approach, and whether either could make it to the clinic.
Browsing: Bacteriophage
Bacteriophage: alternative medicine or an evidence-based alternative?
Bacteriophage have been touted as the solution for antibiotic resistant microbes, why are they not being used in mainstream medicine?
Inevitable triangle interaction in phage therapy: phages – bacteria – immune system
In this opinion piece we take a look at the interaction of bacteria, phages and the human immune system. asking how these three components each play a role in phage therapy?
SEA-PHAGES: from educational project to treatment prospect – an interview with Graham Hatfull
Graham Hatfull speaks about heading up the SEA-PHAGES project and the role this has played in understanding phage diversity and evolution, in addition to commenting on a recent case where a phage cocktail was used to treat a case of Mycobacterium abscessus.
Novel blood test for tuberculosis could also identify high risk of infection
A novel phage-based blood assay has demonstrated its potential for identifying people at high-risk of developing tuberculosis, in addition to diagnosing established cases.
ASM Microbe: Phages isolated from kitchen sponges
Researchers from the New York Institute of Technology (NYIT, NY, USA) have discovered and characterized two bacteriophages from kitchen sponges.
Engineered phages successfully treat case of drug-resistant Mycobacterium abscessus
Phage therapy using genetically engineered bacteriophages has treated a 15-year-old girl who developed a drug-resistant infection following a lung transplant, as outlined in Nature Medicine.
Phages trigger antiviral responses, helping bacteria to evade the immune system
Pseudomonas aeruginosa uses a phage to trick the host’s immune system into ignoring it, in turn suppressing bacterial clearance from infected wounds, according to new research.
First US clinical trial for intravenous phage therapy gets FDA approval
A first for clinical trials in the US as researchers from the University of California San Diego School of Medicine get US FDA approval to use intravenously-administered bacteriophage therapy in hopes of combatting resistant bacteria.
Lysis vs lysogeny: phages tap into quorum-sensing as control mechanism
A bacteriophage, VP882, has been identified to use bacterial quorum-sensing as a method to control the lysis-lysogeny decision. This is the first time a virus has been shown to detect a bacterial molecule.
