Clinical Trial Archives - Infectious Diseases Hub

4 June, 2019 0

The ASPECT-NP study, rationale, results and repercussions – an interview with Igancio Martin-Loeches and Marin Kollef

ECCMID 2019 saw the first presentation of the results from ASPECT-NP, a randomized, multi-center Phase III trial evaluating Merck’s ZERBAXA® (ceftolozane–tazobactam) for the treatment of patients with ventilated nosocomial pneumonia. In light of this we spoke to investigators Marin Kollef and Ignacio Martin-Loeches about the rationale behind this trial, its design and the key findings.

Malaria

23 April, 2019 0

RTS,S vaccine to enter Phase IV trials in Malawi, Kenya and Ghana

A large-scale trial of RTS,S – the world’s first malaria vaccine to provide partial protection – is due to commence in Malawi, Kenya and Ghana.

Clinical

15 April, 2019 0

ECCMID19: Suvratoxumab completes Phase II for treatment of Staphylococcus aureus in the New Drugs 4 Bad Bugs program

Collaborative research efforts have seen a novel monoclonal antibody, suvratoxumab, complete a Phase II trial targeted towards Staphylococcus aureus. This SAATELLITE study comes as the first clinical trial in the Innovative Medicines Initiative, formed to develop alternative medicines to combat antibiotic resistance.

Malaria

11 March, 2019 0

Experimental antimalarial shows promise in human challenge study

A single, oral dose of antimalarial DSM265 has cleared seven volunteers of a Plasmodium falciparum infection, according to the trial from the Medicines for Malaria Venture.

News

26 February, 2019 0

FDA accepts two NDAs from Merck for Priority Review: February’s industry headlines

Take a look at this month’s industry headlines including Priority Review for two antibacterial agents from Merck (NJ, USA), a clinical trial for a new malaria drug and the launch of omadacycline in the USA.

Parasitic

7 February, 2019 0

New treatments for onchocerciasis – the current clinical pipeline

Some of the challenges with mass ivermectin administration could be addressed with new drugs or drug combinations with higher effect for the parasite – leading us to ask, what new treatments are currently in the clinical pipeline?

News

11 January, 2019 0

First US clinical trial for intravenous phage therapy gets FDA approval

A first for clinical trials in the US as researchers from the University of California San Diego School of Medicine get US FDA approval to use intravenously-administered bacteriophage therapy in hopes of combatting resistant bacteria.

Ebola

26 November, 2018 0

First-ever multi-drug Ebola trial launched in the Democratic Republic of Congo

A new trial has begun in the Democratic Republic of Congo, aiming to collect robust data on the safety and efficacy of investigational Ebola therapeutics.

Viral

22 November, 2018 0

Gastroenteritis in children unscathed by treatment with probiotics

Concurrent major US and Canadian clinical trials prove probiotics to be ineffective in combatting gastroenteritis in children.

Drug Development

8 November, 2018 0

Novel antibiotic effective in the treatment of uncomplicated gonorrhea in Phase II trial

A Phase II, muti-center, randomized, open-label trial has reported that a novel oral antibiotic, zoliflodacin, is effective in the treatment of uncomplicated urogenital gonorrhea.

Microbiome therapeutics – the pipeline for C. difficile infection

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