A team from the Scripps Research Institute have determined the structure of clade C HIV-1 envelope glycoprotein, an immunogen that could be utilized in a future HIV vaccine.
Researchers have utilized mathematical modelling to assess whether US goals for HIV transmission and incidence are possible, discovering a serious reduction is achievable if other key goals are met.
CRISPR/Cas9 has been demonstrated to excise HIV-1 DNA from host tissues in vivo according to new research; this marks a major step towards a permanent cure for HIV infection.
The comparative effectiveness of antiretroviral therapies for HIV: evidence to inform precision public health
This Editorial discusses a Health Economics and Outcomes Research (HEOR) approach to use a formal comparative effectiveness analysis and a network meta-analysis for both first- and second-line ART regimens for adults, adolescents and children.
Given the ability of the microbiota to instruct the immune system and control the inflammatory response, the authors discuss the potential of targeting the microbiota to improve the immune recovery and dampen inflammation during HIV infection.
Researchers have demonstrated in mouse models that HIV can persist in infected macrophages despite antiretroviral therapy, suggesting a new cell reservoir.
Researchers have applied concepts from financial mathematical models to help predict the evolution of HIV proteins with the hope this could improve vaccine design.
This opinion piece discusses the many challenges inherent in caring for HIV+ individuals with new-onset seizure. With more questions than answers in both resource-limited settings and more developed medical environments what do we need to elucidate going forwards?
A new mathematical model suggests that the development of a vaccine against HIV, even if it is only partially effective, could be hugely important for the elimination of HIV worldwide.
Researchers looking at the genome of M. tuberculosis have discovered that HIV co-infection could be influencing how the bacteria are evolving.