Endoplasmic reticulum stress and unfolded protein response in infection by intracellular parasites
In this review, the authors discuss recent findings on unfolded protein response (UPR) induction/modulation by intracellular parasites in host cells.
Browsing: Immune Response
Interleukin-37: a new molecular target for host-directed therapy of tuberculosis
Improved therapeutic strategies are in urgent need for better control and eradication of tuberculosis. In this editorial, the authors evaluate interleukin-37 as a new molecular target for the therapy of tuberculosis.
Could bioelectricity help regulate the innate immune system?
Researchers have discovered that compounds altering transmembrane potential in Xenopus laevis may improve resistance to E. coli infection.
Bioinspired antibiotic therapy shows promise against drug-resistant bacteria
A novel, bioinspired antimicrobial treatment, consisting of iodo-thiocyanate complexes, has demonstrated promising results as a bactericidal compound, according to new research.
Novel drug targets identified to fight off Chlamydia infections
Researchers have utilized CRISPR/Cas9 technology on human induced pluripotent stem cells to identify genes involved in fighting off Chlamydia trachomatis infections.
Lysibodies – a promising new weapon against drug-resistant bacteria?
Components from bacteria-infecting viruses could allow scientists to create hybrid human antibodies that can target carbohydrate molecules found on bacterial cell surfaces.
How can the gut microbiota affect immune recovery in HIV-infected individuals?
Given the ability of the microbiota to instruct the immune system and control the inflammatory response, the authors discuss the potential of targeting the microbiota to improve the immune recovery and dampen inflammation during HIV infection.
Oral vaccination – can adjuvants improve immunity?
Oral delivery of vaccines is an attractive approach but is hampered by a number of challenges. Here, the authors discuss the need to include immunostimulatory adjuvants in oral vaccines to overcome oral tolerance and elicit effector immune responses locally within the intestine.
One year on – Ebola vaccines induce a durable immune response
A Phase I clinical trial has demonstrated two investigational Ebola vaccines generate a durable immune response 1 year after vaccination.
Host–pathogen interactions: how do pathogens escape the process of autophagy?
New findings have identified the exact mechanism by which the bacterium Salmonella typhimurium can escape degradation by autophagy.
