Researchers have reported that, despite control efforts, the incidence of visceral leishmaniasis has risen between 1990 and 2016.
The end of January saw the London Centre for Neglected Tropical Disease Research’s (LCNTDR; UK) annual anniversary event, this year commemorating the sixth anniversary of the London Declaration on Neglected Tropical Diseases (NTDs). Discover more about the research presented in this report.
In this article, from Future Medicinal Chemistry, the researchers synthesize a new series of pyrazolo[1,5-c]pyrimidines via hybridization strategies and evaluate these for in vitro activity against leishmaniasis
New research has demonstrated that the extent of Leishmania infection cycles in line with host circadian rhythms, presenting an opportunity for new therapeutics and optimizing prevention methods.
Martin Olivier, discusses how the nanobiome of vectors may impact the infectious processes of disease, highlighting his work on exosomes in sandflies and leishmaniasis.
Researchers have uncovered the role of inflammasome activation in leishmaniasis progression and severity, demonstrating that inhibiting these pathways may present a potential avenue for future treatments.