Weight cycling has been suggested to have detrimental effects on energy homeostasis and other metabolic pathologies, but the mechanisms initially driving this phenomenon remain to be fully elucidated – here the authors discuss the role of the microbiome.
About AMR: Polymicrobial nature of cystic fibrosis infections could influence outcome of antimicrobial therapy
Several recent papers have investigated how polymicrobial interactions in the cystic fibrosis (CF) lung influence antimicrobial efficacy, demonstrating that microbial metabolites produced by one pathogen can alter the antimicrobial killing of another pathogen.
Researchers examining brains from healthy and Alzheimer’s subjects have discovered a higher overall presence of Actinobacteria (Propionibacterium acnes) suggesting that bacterial presence may contribute to the disease.
Researchers have demonstrated that leishmania infection causes dysbiosis in the skin microbiota of both humans and mice. Moreover, in mice they discovered this dybiosis can be passed to naïve mice after close contact with infected individuals.
A new study has investigated the effects of commonly used topical antimicrobials on the skin microbiome, discovering that antibiotics have a major and long-lasting effect.
This article discusses evidence for phage engagement in regulating immunity, shedding new light on the potential immunoregulatory activities of phages which constitute an abundant part of the microbiome.
Martin Olivier, discusses how the nanobiome of vectors may impact the infectious processes of disease, highlighting his work on exosomes in sandflies and leishmaniasis.
Given the ability of the microbiota to instruct the immune system and control the inflammatory response, the authors discuss the potential of targeting the microbiota to improve the immune recovery and dampen inflammation during HIV infection.
A team of UK-based researchers have been awarded a major grant to investigate the relationship between alterations in the gut microbiota and neurodegenerative disorders.