Some of the challenges with mass ivermectin administration could be addressed with new drugs or drug combinations with higher effect for the parasite – leading us to ask, what new treatments are currently in the clinical pipeline?
Genomics is increasingly being adopted into both research and clinical settings. Here, we speak to Dyann Wirth about the use of genomics in the field of malaria, from what it can uncover about the parasite to the hurdles that need to be overcome moving towards elimination.
Cerebral malaria is the most severe neurological complication of Plasmodium falciparum infection. Here, the authors discuss how NRG-1 could attenuate brain injury and mortality.
The US FDA have approved Krintafel (tafenoquine) for the radical cure of Plasmodium vivax malaria infections, the first approval for such a drug in 50 years.
A new study has estimated that up to 30% of parasite burden could be in the liver and bone marrow of infected individuals, a reservoir that has previously gone undetected and unstudied.
Our sister site, MedChemNet, spoke to Joseph Hargan-Calvopiña, Program Manager at BIO Ventures for Global Health, to find out more about their work in global drug development for neglected tropical diseases.
In a special feature for International Women’s Day, we speak to Dr Bobbi Pritt about her responsibilities, her typical day and the time she received a jar of living fleas in her lab!
The end of January saw the London Centre for Neglected Tropical Disease Research’s (LCNTDR; UK) annual anniversary event, this year commemorating the sixth anniversary of the London Declaration on Neglected Tropical Diseases (NTDs). Discover more about the research presented in this report.
In this article, from Future Medicinal Chemistry, the researchers synthesize a new series of pyrazolo[1,5-c]pyrimidines via hybridization strategies and evaluate these for in vitro activity against leishmaniasis
Researchers have studied the genes affected by Trypanosoma brucei, suggesting that sleeping sickness may affect more functions than sleep and categorizing it as a circadian disorder.
