A new computational model has revealed the mechanism of replication in prions, potentially opening new avenues for drug development against prion diseases.
Browsing: Prion Diseases
New research has suggested that the spread of prions to the brain does not occur via the blood–brain barrier, implicating other mechanisms.
A pioneering treatment, an antibody termed PRN100, is to be given to a patient with sporadic Creutzfeldt-Jakob disease for the first time.
We take a look at the drugs that have been studied as treatments for confirmed prion diseases in humans – either in clinical trials, or on a compassionate, case-by-case basis – and look at what the future might hold for the treatment of prion diseases.
Prions are transmissible agents composed of aggregates of misfolded cellular prion protein (PrP) that cause fatal neurodegenerative diseases. Here the authors looks into what genomics can tell us about prion diseases, and gives a perspective on future needs.