When investigating the effect tolerance to a single drug has when combination therapy is being used to prevent antibiotic resistance, a team of researchers demonstrated that antimicrobial tolerance can promote resistance.
Browsing: Resistance Mechanisms
Published in Nature, new research elucidates the mechanism behind malarial resistance to piperaquine and suggests how this knowledge could be used to combat its spread.
Researchers have observed a bacterial mechanism that allows bacteria to change form and resist antibiotics, without the transfer of resistance genes.
Researchers have discovered that a relatively ancient drug efflux pump from Haemophilus influenzae exports the same antibiotics as its evolved counterpart from Escherichia coli, but was mitigated by a leaky porin channel.
Antibiotic tolerance significantly reduces antibiotic efficacy and contributes to treatment failure; targeting both antibiotic tolerance and antibiotic resistance is critical to develop new antimicrobial strategies that will successfully eradicate hard-to-treat infections.
New research presented at ECCMID has identified a novel association between antimicrobial resistance and climatic factors in Europe.
Mark Blaskovich gives us his thoughts on a recent study he led, published in Nature Communications, where the team re-engineered existing antibiotics to make them more powerful.
Researchers have demonstrated that antibiotic-resistance plasmids persist in the absence of antibiotics, provided that the efficiency of plasmid transfer exceeds a critical threshold, highlighting the limitations of ‘resistance-reversal’ strategies.
Certain clays are proven alternatives to antibiotics and their general antibacterial mechanism has been documented, but will it pay to implement this inexpensive treatment?
A recently published study has uncovered how an antibiotic that targets a metabolic pathway to starve bacteria of a nutrient can lead to cell death, shedding light on the downstream effects that can account for toxicity.