Imaging study reveals how malaria parasites bypass antimalarial drugs
Published in Nature, new research elucidates the mechanism behind malarial resistance to piperaquine and suggests how this knowledge could be used to combat its spread.
Browsing: Resistance Mechanisms
Bacteria can lose cell walls in order to resist antibiotics
Researchers have observed a bacterial mechanism that allows bacteria to change form and resist antibiotics, without the transfer of resistance genes.
Multidrug efflux systems: information on evolution and mechanisms uncovered
Researchers have discovered that a relatively ancient drug efflux pump from Haemophilus influenzae exports the same antibiotics as its evolved counterpart from Escherichia coli, but was mitigated by a leaky porin channel.
Countering antibiotic tolerance to fight resistance
Antibiotic tolerance significantly reduces antibiotic efficacy and contributes to treatment failure; targeting both antibiotic tolerance and antibiotic resistance is critical to develop new antimicrobial strategies that will successfully eradicate hard-to-treat infections.
ECCMID19: Could antimicrobial resistance be linked to climate change?
New research presented at ECCMID has identified a novel association between antimicrobial resistance and climatic factors in Europe.
Supercharged vancomycin to the rescue
Mark Blaskovich gives us his thoughts on a recent study he led, published in Nature Communications, where the team re-engineered existing antibiotics to make them more powerful.
About AMR: Limiting antibiotic use not enough to curb resistance reservoirs
Researchers have demonstrated that antibiotic-resistance plasmids persist in the absence of antibiotics, provided that the efficiency of plasmid transfer exceeds a critical threshold, highlighting the limitations of ‘resistance-reversal’ strategies.
An ancient alternative to antibiotics: Clays
Certain clays are proven alternatives to antibiotics and their general antibacterial mechanism has been documented, but will it pay to implement this inexpensive treatment?
About AMR: Self-destruction in response to nutrient starvation is key to antibiotic activity
A recently published study has uncovered how an antibiotic that targets a metabolic pathway to starve bacteria of a nutrient can lead to cell death, shedding light on the downstream effects that can account for toxicity.
Novel antibiotic resistance genes discovered
Researchers have uncovered novel bacterial genes conferring B1 metallo-β-lactamases, and therefore resistance to last-resort antibiotics the carbapenems.
