Competence-inhibiting drugs may prevent the spread of antibiotic resistance
Novel research suggests that some drugs may prevent the acquisition of resistance genes by preventing the induction of bacterial ‘competence’.
Browsing: Resistance Mechanisms
Does drug tolerance promote antibiotic resistance despite combination therapy?
When investigating the effect tolerance to a single drug has when combination therapy is being used to prevent antibiotic resistance, a team of researchers demonstrated that antimicrobial tolerance can promote resistance.
Imaging study reveals how malaria parasites bypass antimalarial drugs
Published in Nature, new research elucidates the mechanism behind malarial resistance to piperaquine and suggests how this knowledge could be used to combat its spread.
Bacteria can lose cell walls in order to resist antibiotics
Researchers have observed a bacterial mechanism that allows bacteria to change form and resist antibiotics, without the transfer of resistance genes.
Multidrug efflux systems: information on evolution and mechanisms uncovered
Researchers have discovered that a relatively ancient drug efflux pump from Haemophilus influenzae exports the same antibiotics as its evolved counterpart from Escherichia coli, but was mitigated by a leaky porin channel.
Countering antibiotic tolerance to fight resistance
Antibiotic tolerance significantly reduces antibiotic efficacy and contributes to treatment failure; targeting both antibiotic tolerance and antibiotic resistance is critical to develop new antimicrobial strategies that will successfully eradicate hard-to-treat infections.
ECCMID19: Could antimicrobial resistance be linked to climate change?
New research presented at ECCMID has identified a novel association between antimicrobial resistance and climatic factors in Europe.
Supercharged vancomycin to the rescue
Mark Blaskovich gives us his thoughts on a recent study he led, published in Nature Communications, where the team re-engineered existing antibiotics to make them more powerful.
About AMR: Limiting antibiotic use not enough to curb resistance reservoirs
Researchers have demonstrated that antibiotic-resistance plasmids persist in the absence of antibiotics, provided that the efficiency of plasmid transfer exceeds a critical threshold, highlighting the limitations of ‘resistance-reversal’ strategies.
An ancient alternative to antibiotics: Clays
Certain clays are proven alternatives to antibiotics and their general antibacterial mechanism has been documented, but will it pay to implement this inexpensive treatment?