A recently published study has uncovered how an antibiotic that targets a metabolic pathway to starve bacteria of a nutrient can lead to cell death, shedding light on the downstream effects that can account for toxicity.
Browsing: Resistance Mechanisms
Researchers have uncovered novel bacterial genes conferring B1 metallo-β-lactamases, and therefore resistance to last-resort antibiotics the carbapenems.
Julie Kaiser discusses the findings and implications of a recent study published in PNAS modeling the sequence of events that increases the risk of colonization and infection with multidrug-resistant (MDR) bacteria.
Researchers have successfully treated a 68-year old diabetic patient with a personalized bacteriophage-based treatment. The patient suffered from necrotizing pancreatitis that had previously been unresponsive to routine antibiotic treatment.
In this piece, Fabio Gsaller discusses the mechanisms underpinning antifungal resistance in A. fumigatus and his work on the use of 5-flucytosine as a therapeutic agent in managing aspergillosis.