Tuberculosis: ‘Suicide’ toxin–antitoxin system identified as a drug target
Researchers have investigated a toxin–antitoxin system in tuberculosis as a therapeutic target, providing the first high-resolution details.
Browsing: Structural Biology
New protein target identified for the development of novel antibiotics
Scientists have unveiled the molecular architecture of two key proteins required for bacillus cell wall elongation. Inhibiting their interaction could provide a new mode of action for antibiotics against highly resistant bacteria.
Synthetic polio vaccine developed using plants
Researchers have pioneered a synthetic polio vaccine using a plant-based production technique. They suggest their findings could be a major step towards the global eradication of this disease.
Galactofuranose antigens, a target for diagnosis of fungal infections in humans
The use of biomarkers for the detection of fungal infections is of interest to complement histopathological and culture methods. Could chemically synthesized Galactofuranose antigens, reviewed in this paper, be used for the synthesis of artificial carbohydrate-based antigens and in diagnosis?
Structure uncovered for Lassa virus glycoprotein
Researchers have uncovered structural and functional details of a key Lassa virus protein; this new information may aid the development of vaccines and therapeutics in the future.
Structure of clade C HIV-1 envelope glycoprotein determined
A team from the Scripps Research Institute have determined the structure of clade C HIV-1 envelope glycoprotein, an immunogen that could be utilized in a future HIV vaccine.
Structure of Zika protein elucidated
Researchers have determined the full structure of Zika protein NS5; a protein is crucial for viral replication and which could present a target for future drug development.
